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KMID : 0032220140260050624
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Annals of Dermatology
2014 Volume.26 No. 5 p.624 ~ p.627
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Alopecia Neoplastica due to Gastric Adenocarcinoma Metastasis to the Scalp, Presenting as Alopecia: A Case Report and Literature Review
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Kim Jung-Hee
Kim Min-Joong
Sim Woo-Young
Lew Bark-Lynn
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Abstract
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Alopecia neoplastica is defined as hair loss secondary to a visceral malignancy that has metastasized to the scalp. The scalp is a relatively common site of cutaneous metastasis, usually presenting as a single or multiple firm scalp nodules. Alopecia neoplastica is a well-recognized but rare presentation, and its pathogenesis is incompletely understood. Atrophy of the hair follicles due to tumor invasion of the scalp plays a role in the development of alopecia. Herein, we describe a 33-year-old woman with gastric adenocarcinoma who developed alopecia neoplastica while receiving cancer chemotherapy. Scalp biopsy revealed metastatic adenocarcinoma cells interspersed be-tween collagen bundles and around hair follicles. Immunohisto-chemical analysis indicated that the tumor cells originated from the primary gastric adenocarcinoma. Therefore, she was diagnosed with alopecia neoplastica due to gastric adenocarci-noma. The findings from this report may be helpful for under-standing the mechanism of alopecia neoplastica. (Ann Dermatol 26(5) 624∼627, 2014)
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KEYWORD
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Alopecia neoplastica, Gastric adenocarcinoma, Scalp metastasis
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